With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4769-97-5,4-Nitroindole,as a common compound, the synthetic route is as follows.,4769-97-5
General procedure: Sodium hydride (1.2 g, 50 mmol) was added portionwise to a solution of 4-nitroindole 1 (8.2 g, 50 mmol) in abs. DMF (50 mL) cooled in an ice bath. Methyl iodide (3.27 mL, 55 mmol) or corresponding alkyl bromide (55 mmol) was added dropwise and the reaction stirred for 4 h at room temperature with TLC analysis monitoring for the completion of the reaction. The solvent was removed under vacuum and the residue partitioned between ethyl acetate and water. The organic phase was dried over magnesium sulfate and the solvent evaporated to give residue. 1-Methyl-4-nitro-1H-indole (2). Yellow solid, mp 112-113, yield 95%. 1H NMR (300 MHz, DMSO-d6) delta 8.09 (d, 1H, J = 8.7 Hz, H-5), 7.99 (d, 1H, J = 8.7 Hz, H-7), 7.76 (d, 1H, J = 3.0 Hz, H-2), 7.36 (t, 1H, J = 8.1 Hz, H-6), 7.03 (d, 1H, J = 3.0 Hz, H-3), 3.93 (s, 3H, CH3-1). Calcd. for C9H8N2O2: C, 61.36; H, 4.58; N, 15.90; Found: C, 61.50; H, 4.30; N, 15.70%.
The synthetic route of 4769-97-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Halaiev, Olexandr; Garazd, Myroslav; Gzella, Andrzej; Lesyk, Roman; Tetrahedron Letters; vol. 58; 13; (2017); p. 1324 – 1325;,
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