With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52488-36-5,4-Bromo-1H-indole,as a common compound, the synthetic route is as follows.
Under a nitrogen atmosphere, cuprous iodide (3.0 mol%, 0.7 mg), sodium iodide (1.0 equiv., 18.7 mg) and magnets were added to a previously baked 10 mL glass pressure tube. Dioxane (0.2 mL), 4-bromoindole (0.125 mmol, 1.0 equiv., 24.5 mg) and N,N’-dimethylethylenediamine (10.0 mol%, 1.1 mg) were then added. After the addition, the glass pressure tube was placed in a metal module that had been preheated to 100 C. and stirred for 10 hours. Cooled to room temperature, cuprous oxide was added under a nitrogen atmosphere (20mol%, 3.6mg), nine carbonyl iron (3mol%, 1.4mg), N- methylpyrrolidinone (0.5mL) and phenyl silane (3.0equiv., 40.6 Mg). The tube was purged of air and charged with carbon dioxide (5.0 equiv., 15 mL) and ammonia gas (5.0 equiv., 15 mL). After the addition was completed, the reactor was placed in a metal module preheated to 160C and stirred for 10 hours. After the reaction was completed, the reaction system was cooled to room temperature and pressure was slowly released. Use of dodecane as an internal standard through gas chromatography The working curve determines that the yield is 84%., 52488-36-5
52488-36-5 4-Bromo-1H-indole 676494, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Li Yuehui; Wang Hua; Dong Yanan; Ke Lisitian¡¤shanduofu; (20 pag.)CN108017557; (2018); A;,
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