With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.525593-33-3,3-Bromo-5-nitroindole,as a common compound, the synthetic route is as follows.
To a stirred solution of 3-bromo-5-nitro-lH-indole (2) (100.0 g, 0.414 mol) in DMF (1 L) was added NaH (19.9 g, 0.829 mol) at 0 C and the solution was stirred for 0.5 h. Methyl iodide (87.7 g, 0.622 mol) was then added to the reaction mixture and the solution was stirred at RT for another 2 h. After completion of reaction the mixture was quenched with water and extracted with ethyl acetate. The organic extract was dried over anhydrous sodium sulphate, filtered and solvents evaporated from the filtrate under reduced pressure to obtain a crude, which was purified by column chromatography on silica gel (100-200 mesh), eluted with 10-15% gradient of EtOAc in pet-ether, to afford 3 -bromo-l -methyl-5 -nitro-lH- indole (101.0 g, 95%)., 525593-33-3
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Reference：
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; SRIVARI, Chandrasekhar; MAINKAR, Prathama Satyendra; REDDY, Chada Raji; KOTAMRAJU, Srigiridhar; TOGAPUR, Pavan Kumar; MUPPIDI, Subbarao Mohan Venkata; SHARMA, Somesh; JHA, Ashok Kumar; ARUMUGAM, Prem Kumar; (27 pag.)WO2019/102488; (2019); A1;,
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