With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6625-96-3,5-Nitro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
6625-96-3, Phthalic anhydride (1) (10 mM) and hydrazine hydrate (2) (10 mM) were added to [DBUH][OAc] (50 mM) and heated for 10 min at 60-65 C to form phthalhydrazide as an intermediate. Then, to this reaction mixture were added 5-nitroindole-3-carboxaldehydes (3a) (10 mM) and malanonitrile/ethylcyano acetate (4) (10 mM). The reaction mixture was heated for 20-35 min until no starting materials could be detected by TLC. Upon completion of the process, cold water was added and thevsolid residue was filtered off. The corresponding product 5 was recrystallized from ethanol. 3-Amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile (5a). mp >220C. IR spectrum, nu, cm-1: 3116-3440 br.m (NH), 2218 s (CN), 1669 s (CO, amide), 1686 s (CO, amide). 1H NMR spectrum, delta, ppm: 5.67 s (1H, CH), 7.26-8.68 m (10H, Ar-H, NH2), delta11.87 s (1H, NH). 13C NMR spectrum, delta, ppm: 61.5, 69.1, 110.6, 111.5, 115.8, 115.9, 119.2, 122.9, 123.6, 127.6, 134.6, 135.6, 138.4, 144.6, 145.8, 161.6, 164.5. MS: m/z: 400 [M+ H]+
The synthetic route of 6625-96-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jeevan Raghavendra; Siddaiah; Russian Journal of General Chemistry; vol. 88; 9; (2018); p. 1892 – 1898; Zh. Obshch. Khim.; vol. 88; 9; (2018); p. 1892 – 1898,7;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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