With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6960-42-5,7-Nitro-1H-indole,as a common compound, the synthetic route is as follows.
6960-42-5, To a solution of 7-nitro-indole (5.00 g, 30.84 mmol) in DMF (30 mL) was added bromine (1.6 mL, 33 mmol), and the mixture was stirred at rt for 8 h.Then the reaction mixture was quenched with a saturated aqueous sodium thiosulfate solution (100 mL), and the mixture was extracted with EtOAc (150 mL x 3). The combined organic layers were washed with saturated brine (100 mLx 3), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo,and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as yellow powder (7.21 g, 97%).MS (ESI, pos. ion) m/z: 242.95 [M+Hfb.
The synthetic route of 6960-42-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (264 pag.)WO2018/33082; (2018); A1;,
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