With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74420-02-3,4-Hydroxy-7-azaindole,as a common compound, the synthetic route is as follows.,74420-02-3
A solution of 1 ,2,3-trifluoro-5-nitrobenzene (CAS No. [66684-58-0]; 3.59 g, 20.3 mmol) and 1 H- pyrrolo[2,3-b]pyridin-4-ol (CAS No. [74420-02-3]; 1 .10 eq., 2.99 g, 22.3 mmol) in DMSO (65 mL) was treated with potassium carbonate (4.00 eq, 1 1 .2 g, 81.1 mmol) and stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate (500 mL) and washed with water (3 x 200 mL) and brine (150 mL), dried with sodium sulfate and concentrated in vacuo. The obtained material was purified by flash chromatography (S1O2- hexane/ ethyl acetate) to give the title compound (3.1 g, 52percent). LC-MS (method 2): Rt = 1 .13 min; MS (ESIpos): m/z = 292 [M+H]+. 1H-NMR (400 MHz, DMSO-d6) delta [ppm] = 6.35 (d, 1 H), 6.59 (d, 1 H), 7.47 (d, 1 H), 8.13 (d, 1 H), 8.37 – 8.43 (m, 2H), 1 1 .97 (br s, 1 H).
As the paragraph descriping shows that 74420-02-3 is playing an increasingly important role.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG; BAYER AKTIENGESELLSCHAFT; BUCHMANN, Bernd; SCHMEES, Norbert; MOWAT, Jeffrey Stuart; LEDER, Gabriele; PANKNIN, Olaf; CARRETERO, Rafael; AIGUABELLA FONT, Nuria; BRIEM, Hans; FRIBERG, Anders Roland; HUSEMANN, Manfred; BOeMER, Ulf; STOeCKIGT, Detlef; NEUHAUS, Roland; BERNDT, Sandra; PETERSEN, Kirstin; OFFRINGA, Rienk; (494 pag.)WO2018/228920; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles