Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 76-60-8, is researched, Molecular C21H14Br4O5S, about Phospholipase-A2 receptor antibody, 24 hours proteinuria, and serum albumin as indicators of cyclophosphamide efficacy in idiopathic membranous nephropathy, the main research direction is cyclophosphamide renoprotectant idiopathic membranous nephropathy; 24h proteinuria; Idiopathic Membranous Nephropathy; PLA2R-Ab; cyclophosphamide; prediction; remission.SDS of cas: 76-60-8.
Background : We aimed to evaluate cyclophosphamide efficacy in the treatment of idiopathic membranous nephropathy (IMN) and explore the efficacy of phospholipase-A2 receptor antibody (PLA2R-Ab), 24 h proteinuria, and serum albumin in predicting 6- and 12-mo treatment effects. Methods : A retrospective anal. was performed on 135 patients with IMN who followed up after treatment. The observation points were before, and after 3, 6, and 12 mo of treatment. We collected clin. indicator data at each observation point and measured PLA2R-Ab levels before and after 3-mo treatment. Results : The remission rates at 3, 6, and 12 mo of cyclophosphamide therapy for patients with IMN were 41.4, 74.8, and 76.1%, resp. Patients in whom PLA2R-Ab turned neg. within 3 mo had high remission rates at 3, 6, and 12 mo after treatment (P < .05). PLA2R-Ab change at 3 mo had a strong correlation with 24 h proteinuria change at 6 mo. The change in albumin concentration before and after 3-mo treatment was an independent variable related to remission rate at 6 mo, and 24 h proteinuria change before and after 6-mo treatment was an independent variable related to remission rate at 12 mo after treatment. Conclusion : Cyclophosphamide showed good efficacy at 3, 6, and 12 mo for patients with IMN. Serum albumin change and PLA2R-Ab change at 3 mo can be used as indicators to predict remission at 6 mo, resp. Moreover, 24 h proteinuria change at 6 mo can predict remission at 12 mo. As far as I know, this compound(76-60-8)SDS of cas: 76-60-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles