885519-01-7, 6-Bromo-4-chloro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
885519-01-7, [00611] To a solution of 6-bromo-4-chloro-1H-indole (200mg, 0.868 mmol) in 5 mL of DMF was added NaH (45.8 lmg, 1.91mmol) at 0 C and the mixture was stirred at 0 C for 1 h. SEMC1 (0.2 mL, 0.561mmol) was added dropwise slowly at 0 C and stirred at rt for 12 h. The reaction mixture was added dropwise slowly to a cold saturated aqueous NaHC03 solution at 0 C. The mixture was extracted with EtOAc (20 mL><2), and the organic layers were washed with water, brine, dried and concentrated. The crude was purified by SGC ( PE/EtOAc=100: l) to give 6-bromo-4-chloro-1H-indole (260mg, 83%) as a yellow oil. MS (EI+, m/z): 361 [M]+.
885519-01-7 6-Bromo-4-chloro-1H-indole 24728099, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles