With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.933-67-5,7-Methyl-1H-indole,as a common compound, the synthetic route is as follows.
In the round bottom flask, ionic liquid [Betaine] [H2PO4] (0.03 mmol), 7-methyl hydrazine (0.3 mmol), and octanol (0.3 mmol) were added in this order, and the mixture was stirred at 50 C, and the whole reaction was carried out. The process was monitored by TLC and reacted for 3 h. Finally, the reaction mixture is extracted with water and ethyl acetate mixture, and after multiple extractions, the organic phase is combined, and the organic phase is steamed under reduced pressure.The crude product was obtained.The crude product was subjected to silica gel column chromatography.Separation gave the pure target product in a yield of 92%., 933-67-5
The synthetic route of 933-67-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Henan Normal University; Zhu Anlian; Feng Wanlu; Cheng Shuang; (7 pag.)CN110041313; (2019); A;,
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