With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.935269-27-5,3-Oxoisoindoline-4-carboxylic acid,as a common compound, the synthetic route is as follows.
935269-27-5, Compound 16f was coupled with 4-methoxyaniline using a coupling agent such as EDCI in DMF to give 3-oxo-2,3-dihydro-lH-isoindole-4-carboxylic acid (4- methoxy-phenyl)-amide Compound 16g 1H NMR (300 MHz, MeOD) 3.80 (s, 3H), 4.56 (s, 2H), 6.94 (d, J = 9 Hz, 2H), 7.70 (d, J = 9 Hz, 2H), 7.78 (m, 2H), 8.40 (m, IH); MS (ESI) m/z: 283 (MH+).
The synthetic route of 935269-27-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/47646; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles