With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.938465-52-2,1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide,as a common compound, the synthetic route is as follows.
938465-52-2, A mixture of 4-((tert-butyldimethylsilyl)oxy)-2,7-diazaspiro [4.5j decan- 1-one (300 mg, 1.22 mmol), 1-chloro-5H-pyrido[4,3-bjindole-4-carboxamide (417 mg, 1.46 mmol) and DIPEA (630 mg, 4.88 mmol) in 1-methylpyrrolidin-2-one (4 mL) was stirred in a microwave at15OC for 1.5 h. To the mixture was added water (10 mL) and DCM (50 mL). After partition, the aqueous layer was extracted with DCM/i-PrOH (v:v=3: 1, 20 mL x 3). The combined organic layers were washed with brine (10 mL), dried over sodium sulfate, filtered and concentrated to afford the cmde product, which was purified by silica gel columnchromatography (MeOH / DCM = 0% 10 %) to give 1-(4-((tert-butyldimethylsilyl)oxy)- 1 -oxo-2,7-diazaspiro[4. 51 decan-7-yl)-5H-pyrido[4,3-bj indole-4- carboxamide. MS: 494.2 [M+Hf?.
The synthetic route of 938465-52-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles