An article Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles WOS:000460577700005 published article about PRENYLATED ISOFLAVONOIDS; NATURAL ISOFLAVONOIDS; MEDICINAL CHEMISTRY; FLUORINE; DERIVATIVES; DISCOVERY; DESIGN; INHIBITORS; BIOISOSTERES; LIGANDS in [Izquierdo, Javier; Jain, Atul D.; Schiltz, Gary E.] Northwestern Univ, Ctr Mol Innovat & Drug Discovery, Evanston, IL 60208 USA; [Abdulkadir, Sarki A.] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA; [Abdulkadir, Sarki A.; Schiltz, Gary E.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA; [Schiltz, Gary E.] Northwestern Univ, Dept Pharmacol, Chicago, IL 60611 USA in 2019.0, Cited 75.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4
The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF (3) ), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.
Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Izquierdo, J; Jain, AD; Abdulkadir, SA; Schiltz, GE or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles