Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.87-99-0, Name is Xylitol, SMILES is OC[C@@H]([C@H]([C@@H](CO)O)O)O, belongs to indole-building-block compound. In a document, author is Li, Yuanyuan, introduce the new discover, SDS of cas: 87-99-0.
Structural insights into the design of indole derivatives as tubulin polymerization inhibitors
Microtubules are composed of alpha beta-tubulin heterodimers, and drugs that interfere with microtubule dynamics are used widely in cancer chemotherapy. Small synthetic molecules with an indole nucleus as a core structure have been identified as microtubule inhibitors and recognized as anticancer agents. However, structural information for the interactions between indole derivatives and tubulin is sparse. Here, we present the 2.55 angstrom crystal structure of tubulin in complex with the indole derivative D64131. We compare the binding modes of D64131, colchicine, and five other indole derivatives to tubulin. These results reveal the interactions between the indole derivatives and tubulin, explain previous results of structure-activity-relationship (SAR) studies and, thus, provide insights into the development of new indole derivatives targeting the colchicine binding site.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 87-99-0 is helpful to your research. SDS of cas: 87-99-0.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles