Nguyen, Sierra C.;Hong, Allen Y. published 《Synthesis of semi-saturated polycyclic 1,2,4-triazoles from lactams》. The research results were published in《Tetrahedron Letters》 in 2021.Application of 132680-54-7 The article conveys some information:
A two-step method for the preparation of annulated 1,2,4-triazoles has been developed via the hydroxylamine-O-sulfonic acid (HOSA)-mediated N-amination of readily available lactams followed by condensation with Et 2-ethoxy-2-iminoacetate. Various annulated ring sizes can be incorporated into the resulting polycyclic triazoles. The experimental procedure involved many compounds, such as 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Application of 132680-54-7) is a class III topoisomerase inhibitor that binds to the chk1 protein, which is an enzyme involved in DNA replication. 6-Methoxyisoindolin-1-one inhibits the interaction between the chk1 protein and DNA, preventing DNA replication.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles