Nilsson, Kurt et al. published their patent in 1995 |CAS: 130539-43-4

The Article related to lactosamine derivative production lactose transglycosylation galactosidase, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Application In Synthesis of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside

On July 13, 1995, Nilsson, Kurt published a patent.Application In Synthesis of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside The title of the patent was Method of producing derivatives of lactosamine. And the patent contained the following:

Disclosed is a method of producing compounds with β1-4 linkage which contains the lactosamine structure involving reacting ≥1 donor substance GalβOR where R is an organic group, and ≥1 acceptor substance which is a glucopyranosamino derivative having the formula GlcNR’-R”, wherein NR’ is an azido, 2-N-acetyl-, 2-N-phthalimido, or an organic group bound to the 2-N group of glucosamine, wherein R” is a glycosidically bound F- or is an O-, C-, N-, or S- glycosidically bound aliphatic or aromatic compound, with the proviso that if NR’ is NHAc then R” is not OH and if NR’ is not NHAc then R” may be OH, in the presence of Bullera singularis or an E.C. group 3.2 glycosidase of essentially the same structure as an E.C. group 3.2 glycosidase obtained from B. singularis to form the lactosamine derivative; and optionally isolating the compound with β1-4 linkage which contains the lactosamine structure. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).Application In Synthesis of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside

The Article related to lactosamine derivative production lactose transglycosylation galactosidase, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Application In Synthesis of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles