Nirogi, Ramakrishna; Gagginapally, Shankar Reddy; Shinde, Anil K.; Mohammed, Abdul Rasheed published the artcile< Synthesis of GR125487, a selective 5-HT4 receptor antagonist>, HPLC of Formula: 23077-43-2, the main research area is GR125487 synthesis serotonin receptor 5HT4 antagonist cognition.
The 5-HT4 receptor (5-HT4R) agonists are important in treating gastrointestinal motility disorders. Their role is currently being evaluated for the treatment of cognitive and mood disorders. A selective 5-HT4R antagonist GR 125487 is used in many biol. assays to cross confirm the 5-HT4R agonist’s activity. A practical synthesis of GR 125487 is developed so as to have it in desired quantities. The synthesis consists of seven steps starting from com. available Me 5-fluoroindole 3-carboxylate. The GR 125487 thus synthesized was used in blocking the activity of 5-HT4R agonist compound in animal models of cognition.
Synthetic Communications published new progress about 5-HT4 agonists. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, HPLC of Formula: 23077-43-2.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles