On October 14, 2004, Nobayashi, Eiji; Fujii, Katsuhiro published a patent.Category: indole-building-block The title of the patent was Preparation of high-purity indolecarboxylic acids from their esters. And the patent contained the following:
Title carboxylic acids are prepared by hydrolysis of their esters I [R1-R6 = H, halo, alkyl, acyl(oxy), alkoxy, aryl, NO2, cyano, etc.; ≥1 of R1-R6 = carboxylic acid ester residue; R7 = H, C1-4 alkyl] with alkali metal hydroxides in nonpolar solvents, H2O, and alcs. Thus, Et 1-methylindole-2-carboxylate was treated with 4.8% aqueous NaOH at 55-59° in MePh and MeOH for 3 h, the organic phase removed, and acidified to give 95% 1-methylindole-2-carboxylic acid with 99.0% purity. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Category: indole-building-block
The Article related to indolecarboxylic acid preparation solvent nonpolar alc water, toluene methanol water solvent hydrolysis indolecarboxylate ester, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles