Authors Webb, EW; Park, JB; Cole, EL; Donnelly, DJ; Bonacorsi, SJ; Ewing, WR; Doyle, AG in AMER CHEMICAL SOC published article about ALIPHATIC CARBOXYLIC-ACIDS; DECARBOXYLATIVE FLUORINATION; SYNTHETIC METHODS; QUATERNARY CARBONS; FLUORIDE; ALKENES; DEOXYFLUORINATION; HYDROFLUORINATION; AMINOFLUORINATION; DIFLUORINATION in [Webb, Eric W.; Park, John B.; Doyle, Abigail G.] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA; [Cole, Erin L.; Donnelly, David J.; Bonacorsi, Samuel J.] Bristol Myers Squibb Res & Dev, PET Radiochem Synth, Discovery Chem Platforms, Princeton, NJ 08543 USA; [Ewing, William R.] Bristol Myers Squibb, Discovery Chem, Princeton, NJ 08543 USA in 2020.0, Cited 75.0. Application In Synthesis of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination. In addition, we show that the decarboxylative fluorination conditions are readily adapted to radiofluorination with [F-18]KF. We propose that the reactions proceed by two electron transfers between the Ir catalyst and redox-active ester substrate to afford a carbocation intermediate that undergoes subsequent trapping by fluoride. Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalimidoyl oxalates are also presented, suggesting that this approach may offer a general blueprint for affecting redox-neutral S(N)1 substitutions under mild conditions.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Webb, EW; Park, JB; Cole, EL; Donnelly, DJ; Bonacorsi, SJ; Ewing, WR; Doyle, AG or concate me.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles