Synthetic Route of 136-77-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 136-77-6, Name is 4-Hexylbenzene-1,3-diol, SMILES is CCCCCCC1=C(O)C=C(O)C=C1, belongs to indole-building-block compound. In a article, author is Ibanez, Ignacio, introduce new discover of the category.
Enantioselective Friedel-Crafts Alkylation Reaction of Indoles with alpha-Trifluoromethylated beta-Nitrostyrenes Catalyzed by Chiral BINOL Metal Phosphate
An efficient enantioselective Friedel-Crafts alkylation reaction of indoles with alpha-CF3-substituted beta-nitrostyrenes is disclosed. The key to success is the use of a chiral calcium BINOL bis(phosphate) complex as a Lewis acid catalyst. The reaction gives access to a wide variety of optically active indoles bearing trifluoromethylated all-carbon quaternary stereocenter (up to 20 examples) in high yields (up to 99%) with excellent enantioselectivities (up to 98%) under mild reaction conditions. Non activated alpha-alkyl-beta-nitrostyrenes also participated in the Friedel-Crafts alkylation reaction successfully.
Synthetic Route of 136-77-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 136-77-6.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles