In an article, author is Bhat, Aabid H., once mentioned the application of 1953-54-4, Name is 5-Hydroxyindole, molecular formula is C8H7NO, molecular weight is 133.1473, MDL number is MFCD00005677, category is indole-building-block. Now introduce a scientific discovery about this category, SDS of cas: 1953-54-4.
The decomposition of diazodicarbonyl compounds in the presence of various metal catalysts has become a reliable method for the functionalization of indoles via carbenoid intermediates. Exploiting the nucleophilic reactivity of the in situ generated malonic ester product formed, we herein report a tandem C-H functionalization/Conia-ene cyclization of N-alkyne tethered indoles. This double functionalization of diazodicarbonyls generates a range of pyrrolo[1,2-a] pyrido[1,2-a]-, and azepino[1,2-a]indole products with good synthetic efficiency.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles