The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 34580-14-8, Name is Ketotifen fumarate, SMILES is O=C(C1=C2C=CS1)CC3=CC=CC=C3C2=C4CCN(C)CC4.O=C(O)/C=C/C(O)=O, in an article , author is Lin Wei, once mentioned of 34580-14-8, Recommanded Product: Ketotifen fumarate.
Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction
The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles