Recently I am researching about VISCERAL LEISHMANIASIS; IN-VITRO; 2-SUBSTITUTED QUINOLINES; BIOLOGICAL EVALUATION; ANTIMALARIAL; CHEMOTHERAPY; DERIVATIVES; COMPLEXES; DISCOVERY; EFFICACY, Saw an article supported by the . Safety of 4′-Hydroxyacetophenone. Published in HINDAWI LTD in LONDON ,Authors: Abdelwahid, MAS; Elsaman, T; Mohamed, MS; Latif, SA; Mukhtar, MM; Mohamed, MA. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
Leishmaniasis is a fatal neglected parasitic disease caused by protozoa of the genus Leishmania and transmitted to humans by different species of phlebotomine sandflies. The disease incidence continues to increase due to lack of vaccines and prophylactic drugs. Drugs commonly used for the treatment are frequently toxic and highly expensive. The problem of these drugs is further complicated by the development of resistance. Thus, there is an urgent need to develop new antileishmanial drug candidates. The aim of this study was to synthesize certain quinoline-4-carboxylic acids, confirm their chemical structures, and evaluate their antileishmanial activity. Pfitzinger reaction was employed to synthesize fifteen quinoline-4-carboxylic acids (Q1-Q15) by reacting equimolar mixtures of isatin derivatives and appropriate -methyl ketone. The products were purified, and their respective chemical structures were deduced using various spectral tools (IR, MS, H-1 NMR, and C-13 NMR). Then, they were investigated against L. donovani promastigote (clinical isolate) in different concentration levels (200g/mL to 1.56g/mL) against sodium stibogluconate and amphotericin B as positive controls. The IC50 for each compound was determined and manipulated statistically. Among these compounds, Q1 (2-methylquinoline-4-carboxylic acid) was found to be the most active in terms of IC50.
Safety of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Abdelwahid, MAS; Elsaman, T; Mohamed, MS; Latif, SA; Mukhtar, MM; Mohamed, MA or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles