Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 15231-91-1, Name is 6-Bromo-2-naphthol, molecular formula is C10H7BrO, belongs to indole-building-block compound. In a document, author is Dinda, Enakshi, introduce the new discover, Application In Synthesis of 6-Bromo-2-naphthol.
Palladium-Catalyzed Cascade Reactions for Annulative pi-Extension of Indoles to Carbazolcs through C-H Bond Activation
The annulative pi-extension (APEX) reactions through C-H bond activation has tremendous potential to access fused aromatic systems from relatively simple aromatic compounds in a single step. This state-of-the-art technique has the ability to streamline the synthesis of functionalized materials useful in material science, biomedical research, agroand pharmaceutical industries. Furthermore, C-H activation strategy does not require pre-functionalization steps, which allows for the late-stage modification of the functional molecule with requisite molecular properties. Owing to their unique photophysical properties, carbazoles are widely used in photovoltaic cells, biomedical imaging, fluorescent polymer, etc. It is also ubiquitously found in many natural products, agrochemicals and privileged medicinal scaffolds. Hence, direct conversion of easily accessible indole to carbazole remains an active research area. In the last decades, significant advancement has been made to access carbazole moiety directly from indole through cascade C-H activation. The underlying mechanism behind this cascade pi-extension strategy is the facile electrophilic metalation at the C-3 position of the indole moiety, 1,2- migration and electro cyclization. In this review, we will discuss recent literature reports for the palladium-catalyzed pi-extension of indole to carbazole moiety through C-II bond activation.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 15231-91-1. Application In Synthesis of 6-Bromo-2-naphthol.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles