The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 97-53-0, Name is Eugenol, SMILES is COC1=CC(CC=C)=CC=C1O, in an article , author is Zhao, Yunlong, once mentioned of 97-53-0, Formula: https://www.ambeed.com/products/97-53-0.html.
The first solvent-mediated tunable C3/C7 regio- and enantioselective Friedel-Crafts alkylation of 4-aminoindoles with alpha-ketimino esters has been developed. This catalysis allows the highly regioselective formation of indole C3 and C7 alkylation products, both in high yields (up to 96%) and excellent enantioselectivities (up to 99% ee). Mechanism study revealed that the hydrogen-bonding interactions of the solvents with the catalyst played a vital role for the regioselectivity switch. Furthermore, the corresponding products are indole containing unnatural alpha-amino acid derivatives bearing a quaternary stereocenter and enable many further elaborations.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles