Recommanded Product: 4′-Hydroxyacetophenone. Jeong, J; Kim, KH; Kim, DY; Chandrasekaran, G; Kim, M; Pagire, SH; Dighe, M; Choi, EY; Bak, SM; Kim, EY; Shin, MG; Choi, SY; Ahn, JH in [Jeong, Jieun; Kim, Minhee; Pagire, Suvarna H.; Dighe, Mahesh; Ahn, Jin Hee] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; [Kim, Kun-Hee; Chandrasekaran, Gopalakrishnan; Choi, Seok-Yong] Chonnam Natl Univ, Dept Biomed Sci, Med Sch, Gwangju, South Korea; [Kim, Dong-Young] Univ Ulsan, Coll Med, Dept Biomed Sci, Seoul, South Korea; [Bak, Su-Min; Kim, Eun-Young] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea; [Bak, Su-Min; Kim, Eun-Young] Kyung Hee Univ, Dept Biol, Seoul, South Korea; [Shin, Myung-Geun] Chonnam Natl Univ, Dept Lab Med, Med Sch, Gwangju, South Korea published Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model in 2019.0, Cited 18.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
A new series of 1,3-diketone, heterocyclic and alpha, beta-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jeong, J; Kim, KH; Kim, DY; Chandrasekaran, G; Kim, M; Pagire, SH; Dighe, M; Choi, EY; Bak, SM; Kim, EY; Shin, MG; Choi, SY; Ahn, JH or concate me.. Recommanded Product: 4′-Hydroxyacetophenone
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles