An article Preparation and controlled drug release ability of the poly [N-isopropylacryamide-co-allyl poly(ethylene glycol)]-b-poly(gamma-benzyl-L-glutamate) polymeric micelles WOS:000461526800090 published article about AMPHIPHILIC BLOCK-COPOLYMER; POLY(GAMMA-BENZYL L-GLUTAMATE); POLYPEPTIDE NANOGELS; COMPLEX MICELLES; IN-VITRO; NANOPARTICLES; TEMPERATURE; DELIVERY; CORE; POLY(N-ISOPROPYLACRYLAMIDE) in [Sang, Xinxin; Yang, Qiyi; Zhang, Liping; Ni, Caihua] Jiangnan Univ, Minist Educ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Wuxi 214122, Peoples R China; [Wen, Quanwu] Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China in 2019.0, Cited 35.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Recommanded Product: 100-51-6
The polymeric micelles were prepared through a copolymerization of allyl polyethylene glycol (APEG) and N-isopropylacrylamide in the presence of 2-aminoethanethiol (AET), followed by a ring opening polymerization of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA). Doxorubicin (DOX) as a model drug was covalently conjugated into the core of micelles via hydrazone bonds. The drug loading capacity could reach up to 15% with drug encapsulation efficiency of 80%. The pH/thermo sensitivities were observed in the process of in vitro drug release. The DOX-loaded micelles exhibited accelerated drug release behaviors in an acidic condition, and enhanced therapeutic efficacy was observed. Furthermore, the cytotoxicity of micelles against Hela and 3T3 cells was evaluated before and after drug loading. The DOX-loaded micelles showed strong cytotoxic activity to the cancer cells. But the blank micelles showed non-cytotoxicity. Therefore, the thermo/pH dual-responsive polymeric micelles have a promising future applied as a controlled drug delivery system for anticancer drugs.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles