One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 119-36-8, Name is Methyl Salicylate, formurla is C8H8O3. In a document, author is Sun, Peng, introducing its new discovery. HPLC of Formula: C8H8O3.
Copper-Mediated One-Pot Synthesis of Indoles through Sequential Hydroamination and Cross-Dehydrogenative Coupling Reaction
Starting from simple anilines and ester arylpropiolates, an efficient one-pot synthesis of 2-arylindole-3-carboxylate derivatives has been developed through copper-mediated sequential hydroamination and cross-dehydrogenative coupling (CDC) reaction. The initial hydroamination of anilines to ester arylpropiolates in benzene can proceed in a stereoselective manner to give ester (Z)-3-arylamino)acrylates in the presence of CuCl2/phenanthroline, KMnO4, and KHCO3 at 120 degrees C. Sequentially, these in situ functionalized adducts can undergo direct intramolecular oxidative alkenylation of aromatic C-H bond in mixed solvents (benzene/DMSO 1:1) at 130 degrees C affording multi-substituted indoles in good to high yields.
If you are hungry for even more, make sure to check my other article about 119-36-8, HPLC of Formula: C8H8O3.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles