On November 5, 2015, Okano, Tsubasa; Suzuki, Shinya published a patent.Product Details of 52537-00-5 The title of the patent was Preparation of imidazoline derivatives as selective adrenaline α1A receptor full agonists. And the patent contained the following:
Disclosed are compounds I [A = Q1, Q2 or Q3; R = halo; n = 1-4; or pharmaceutically acceptable salts thereof]. For example, II·2HCl was prepared via reaction of 5-chloroindolin-2-one with TMEDA/n-BuLi/1,2-dibromoethane, reduction, cyanomethylation with bromoacetonitrile, treatment with ethylenediamine/P2S5 and salt-formation. In adrenaline receptor α1 agonist activity test, the exemplified compound II·2HCl showed EC50 values (nmol/L) of 2.60 and >10000 for α1A and α1L, resp. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Product Details of 52537-00-5
The Article related to imidazoline preparation selective adrenaline alpha 1a receptor full agonist, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles