On February 21, 2005, Ori, Mayuko; Toda, Narihiro; Takami, Kazuko; Tago, Keiko; Kogen, Hiroshi published an article.Recommanded Product: 79815-20-6 The title of the article was Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin. And the article contained the following:
An efficient methodol. for the synthesis of 2,2,3-trisubstituted tetrahydroquinolines has been developed, which involves the triphenylphosphine-CCl4-mediated stereospecific rearrangement of α,α-disubstituted indoline-2-methanols (I) to 2,2,3-trisubstituted tetrahydroquinolines. The rearrangement precursors I are readily prepared by the diastereoselective Grignard addition to 2-acylindolines. The total syntheses of (+)-benzastatin E (II) and natural virantmycin (III) were accomplished utilizing this methodol. This rearrangement reaction might afford some chem. precedent for the biogenetic pathway of the benzastatin family. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6
The Article related to benzastatin e preparation, virantmycin preparation, tetrahydroquinoline preparation rearrangement indolinemethanol, indoline methanol preparation grignard addition acylindoline and other aspects.Recommanded Product: 79815-20-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles