So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Uzair, U.; Johnson, C.; Beladi, S.; Benza, D.; Raval, Y.; Ranasinghe, M.; Schober, G.; Tzeng, T.-R. J.; Anker, J. N. researched the compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8 ).Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide.They published the article 《Conformal coating of orthopedic plates with X-ray scintillators and pH indicators for X-ray excited luminescence chemical imaging through tissue》 about this compound( cas:76-60-8 ) in ChemRxiv. Keywords: orthopedic plate x ray scintillator pH indicator luminescence imaging. We’ll tell you more about this compound (cas:76-60-8).
The authors describe a material that allows for high spatial resolution pH mapping through tissue using x-ray excited luminescence chem. imaging (XELCI). This is especially useful for detecting implant associated infection and elucidating how the local biochem. environment changes during infection and treatment. To acquire one pixel in the image, a focused x-ray beam irradiates a small region of scintillators coated on the implant and the x-ray excited optical luminescence spectrum is modulated by indicator dyes to provide a chem. sensitive measurement with low background. Scanning the x-ray beam across the implant surface generates high spatial resolution chem. measurements. Two associated challenges are (1) to make robust sensors that can be implanted in tissue to measure local chem. concentrations and specifically for metal orthopedic implants, and (2) to conformally coat the implant surface with scintillators and pH indicator dyes to make measurements over a large area. Previously, the authors have phys. pressed or glued a pH-sensitive hydrogel sensor to the surface of an implant, but this is impractical for imaging over large irregular device areas such as an orthopedic plate with holes and edges. Herein the authors describe a chem. sensitive and biocompatible XELI sensor material containing scintillator particles (Gd2O2S:Eu) and a pH sensitive hydrogel coating using a roughened epoxy coating. A two-part com. grade epoxy film was tested and found to make the coating of pH sensitive layer adhere better to the titanium surface. Sugar and salt particles were added to the surface of the epoxy as it cured to create a roughened surface and increase surface area. On this roughened surface, a secondary layer of diacrylated polyethylene glycol (PEG) hydrogel, containing a pH sensitive dye, was polymerized This layer was found to adhere well to the epoxy-coated implant unlike other previously tested polymer surfaces which delaminated when exposed to water or humidity. The focused x-ray beam enabled 0.5 mm spatial resolution through 1 cm thick tissue. The pH sensor coated orthopedic plate was imaged with XELCI through tissue with different pH to acquire a calibration curve. The plates were also imaged through tissue with low pH region from a Staphylococcus aureus biofilm grown on one section. These studies demonstrate the use of pH sensor coated orthopedic plates for mapping the surface pH through tissue during biofilm formation using XELCI.
As far as I know, this compound(76-60-8)Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles