I found the field of Chemistry very interesting. Saw the article Access to Biphenyls by Palladium-Catalyzed Oxidative Coupling of Phenyl Carbamates and Phenols published in 2019. Safety of 3-(Trifluoromethyl)phenol, Reprint Addresses Bach, T (corresponding author), Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol
The oxidative cross-coupling of phenols (3 equiv) to various substituted phenyl N,N-diethylcarbamates was explored with a variety of substrates. Pd(OAc)(2) was employed as the catalyst (20 mol%) and K2S2O8 as the stoichiometric oxidant in trifluoroacetic acid as the solvent (50 degrees C, 2 h). Carbamates without or with a substituent on the phenyl ring (Me, Ph, Cl, OMe) underwent the reaction unless the phenyl substituent was too strongly electron withdrawing (CN). Cross-coupling occurred exclusively in theorthoposition relative to the carbamate group. The regioselectivity at the phenol (orthoorparato hydroxy) was mainly determined by steric factors. Yields up to 60-70% were achieved for specific carbamate/phenol combinations.
Welcome to talk about 98-17-9, If you have any questions, you can contact Truchan, N; Jandl, C; Pothig, A; Breitenlechner, S; Bach, T or send Email.. Safety of 3-(Trifluoromethyl)phenol
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles