Synthesis and study of new indoline spiropyran and its derivative with 伪-lipoic acid exhibiting low cytotoxicity was written by Ozhogin, I. V.;Zolotukhin, P. V.;Tkachev, V. V.;Pugachev, A. D.;Kozlenko, A. S.;Belanova, A. A.;Aldoshin, S. M.;Lukyanov, B. S.. And the article was included in Russian Chemical Bulletin in 2021.Formula: C12H14ClN This article mentions the following:
New indoline spiropyran was synthesized by the cyclocondensation of 5-chlorine-substituted Fischer base with 2,7-dihydroxy-1-naphthaldehyde. This spiropyran was used to prepare a new derivative of 伪-lipoic acid with potential biol. activity, which can be considered as a promising photopharmacol. agent. The structures of the synthesized compounds were determined by NMR and IR spectroscopy and mass spectrometry and were confirmed by X-ray diffraction. Biol. assays using HeLa cells showed that the spirocyclic compounds possess low cytotoxicity even at relatively high concentrations In the experiment, the researchers used many compounds, for example, 5-Chloro-1,3,3-trimethyl-2-methyleneindoline (cas: 6872-17-9Formula: C12H14ClN).
5-Chloro-1,3,3-trimethyl-2-methyleneindoline (cas: 6872-17-9) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Formula: C12H14ClN
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles