Synthetic studies toward tetrodecamycin: an efficient approach to the core structure of the antibiotic was written by Paintner, Franz F.;Allmendinger, Lars;Bauschke, Gerd;Polborn, Kurt. And the article was included in Synlett in 2002.Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:
An efficient synthetic pathway to the core structure I of the polyketide antibiotic tetrodecamycin has been developed. Our approach features the acid-catalyzed cyclization of a tert-butyldimethylsilyl protected Me 婵?(缂?hydroxyacyl) tetronate, leading to the novel tricyclic ring skeleton exhibited by I. An insight into the mechanism of this key ring closure step has been gained. Furthermore an alternative pathway to this ring skeleton, based on a fluoride ion induced desilylation-cyclization sequence, has been disclosed. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles