Cyclization of Vinylketene Dithioacetals: A Synthetic Strategy for Substituted Thiophenes was written by Pan, Ling;Zheng, Baihui;Yang, Xiaohui;Deng, Liping;Li, Yifei;Liu, Qun. And the article was included in Advanced Synthesis & Catalysis in 2021.HPLC of Formula: 1076-74-0 This article mentions the following:
A synthetic strategy for the synthesis of substituted thiophenes is described by the one-pot reaction of indoles with ketene dithioacetals under mild reaction conditions. Promoted by triflic acid (TfOH), the reaction of indoles with the easily available α-acetyl ketene dithioacetals resulted in the formation of vinylketene dithioacetals via condensation instead of the well known nucleophilic addition-alkylthio elimination process. In the presence of CuBr2, vinylketene dithioacetals can cyclize into the corresponding substituted thiophenes. This transformation may benefit from the acidic reaction conditions and the steric effects of the 2-substituted indoles. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0HPLC of Formula: 1076-74-0).
5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 1076-74-0
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles