Homogeneous cobalt-catalyzed deoxygenative hydrogenation of amides to amines was written by Papa, Veronica;Cabrero-Antonino, Jose R.;Spannenberg, Anke;Junge, Kathrin;Beller, Matthias. And the article was included in Catalysis Science & Technology in 2020.Related Products of 5388-42-1 This article mentions the following:
The first general and efficient cobalt-catalyzed deoxygenative hydrogenation of amides, e.g., I to amines, e.g., II is presented. The optimal catalytic system based on a combination of [Co(NTf2)2] and (p-anisyl)triphos in the presence of [Me, 3SiOTf] as acidic co-catalyst facilitates the direct hydrogenation of a broad range of amides, e.g., I to the corresponding amines e.g., II under mild conditions. A set of control experiments indicate that, after the initial reduction of the amide carboxylic group to the well-known hemiaminal intermediate, the reaction mainly proceeds through C-O bond cleavage though other pathways might be also involved to a minor extent. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Related Products of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Related Products of 5388-42-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles