Simple organocatalyst component system for asymmetric hetero Diels-Alder reaction of isatins with enones was written by Parasuraman, Perumalsamy;Begum, Zubeda;Chennapuram, Madhu;Seki, Chigusa;Okuyama, Yuko;Kwon, Eunsang;Uwai, Koji;Tokiwa, Michio;Tokiwa, Suguru;Takeshita, Mitsuhiro;Nakano, Hiroto. And the article was included in RSC Advances in 2020.Computed Properties of C8H4BrNO2 This article mentions the following:
A simple two catalyst component system consisting of primary β-amino alcs. as a catalyst and amino acids as a co-catalyst put together worked as an efficient organocatalyst system in hetero Diels-Alder reaction of isatins with enones to afford chiral spirooxindole-tetrahydropyranones I [R1 = H, Cl, Br; R2 = H, Me, Br; R3 = H, Cl; R4 = allyl, Pr, iso-Pr, hexyl] in good chem. yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee). In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Computed Properties of C8H4BrNO2).
4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C8H4BrNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles