Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). Recommanded Product: 1H-Indole-2-carbaldehyde.
Perin, N.;Hok, L.;Bec, A.;Persoons, L.;Vanstreels, E.;Daelemans, D.;Vianello, R.;Hranjec, M. research published 《 N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis》, the research content is summarized as follows. The design, synthesis and biol. activity of novel N-substituted benzimidazole based acrylonitriles I (R1 = H, CN; R2 = Me, i-Bu, Ph; R3 = Ph, pyridin-3-yl, 1H-indol-2-yl, etc.) as potential tubulin polymerization inhibitors were presented. Their synthesis was achieved using classical linear organic and microwave assisted techniques, starting from aromatic aldehydes R3CHO and N-substituted-2-cyanomethylbenzimidazoles II. All newly prepared compounds I were tested for their antiproliferative activity in vitro on eight human cancer cell lines and one reference non-cancerous assay. N,N-dimethylamino substituted acrylonitriles I [R1 = H, R2 = i-Bu, R3 = 4-(dimethylamino)phenyl (III); and R1 = CN, R2 = i-Bu, R3 = 4-(dimethylamino)phenyl (IV)], bearing N-iso-Bu and cyano substituents placed on the benzimidazole nuclei, showed strong and selective antiproliferative activity in the submicromolar range of inhibitory concentrations (IC50 0.2-0.6μM), while being significantly less toxic than reference systems docetaxel and staurosporine, thus promoting them as lead compounds Mechanism of action studies demonstrated that two most active compounds III and IV inhibited tubulin polymerization Computational anal. confirmed the suitability of the employed benzimidazole-acrylonitrile skeleton for the binding within the colchicine binding site in tubulin, thus rationalizing the observed antitumor activities, and demonstrated that E-isomers are active substances. It also provided structural determinants affecting both the binding position and the matching affinities and identifying the attached NMe2 group as the most dominant in promoting the binding, which allows ligands to optimize favorable cation…π and hydrogen bonding interactions with Lys352.
19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Recommanded Product: 1H-Indole-2-carbaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles