On June 15, 2007, Perni, Robert B.; Chandorkar, Gurudatt; Cottrell, Kevin M.; Gates, Cynthia A.; Lin, Chao; Lin, Kai; Luong, Yu-Ping; Maxwell, John P.; Murcko, Mark A.; Pitlik, Janos; Rao, Govinda; Schairer, Wayne C.; Van Drie, John; Wei, Yunyi published an article.Related Products of 79815-20-6 The title of the article was Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics. And the article contained the following:
Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3·4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6
The Article related to hepatitis c virus protease inhibitor preparation structure activity, Pharmacology: Structure-Activity and other aspects.Related Products of 79815-20-6
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles