Crucial role of selenium in the virucidal activity of benzisoselenazol-3(2H)-ones and related diselenides was written by Pietka-Ottlik, Magdalena;Potaczek, Piotr;Piasecki, Egbert;Mlochowski, Jacek. And the article was included in Molecules in 2010.Formula: C14H11NO This article mentions the following:
Several substituted 1,2-benzisoselenazol-3(2H)-one derivatives and their non-selenium-containing analogs were designed. The synthesis of the target compounds was achieved using as reactants 2-(chloroseleno)benzoyl chloride and 2-(chlorothio)benzoyl chloride or 2-(chloromethyl)benzoyl chloride and the products thus obtained were evaluated against several viruses (HHV-1, human herpes, EMCV Encephalomyocarditis virus and VSV, Vesicular stomatitis virus) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogs having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogs of benzisoselenazol-3(2H)-ones (diselenides) also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Formula: C14H11NO).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Formula: C14H11NO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles