Synthesis and cytotoxicity evaluation of olivacine-indole hybrids tethered by alkyl linkers was written by Pis Diez, Cristian M.;Cespedes, Mariela;Di Venosa, Gabriela M.;Calvo, Gustavo;Avigliano, Esteban;Casas, Adriana G.;Palermo, Jorge A.. And the article was included in Natural Product Research in 2022.Name: 6-Chloro-1H-indole This article mentions the following:
In this work, eleven new derivatives were prepared of the alkaloid olivacine (1), which was isolated from the bark of Aspidosperma australe. These compounds are hybrids of olivacine and indoles or carbazole, tethered by alkyl chains of variable lengths (C-4, C-5 or C-6). Compounds showed increased cytotoxicity towards a panel of four cell lines. The subcellular localization of olivacine and of the synthetic derivatives was studied by fluorescence microscopy. The cycles of K562 cells exposed to olivacine or compounds were analyzed by flow cytometry, and showed, for some of the new derivatives, a different profile of cell distribution among the phases of the cycle when compared to olivacine, which is indicative of lysosomal apoptosis. In the experiment, the researchers used many compounds, for example, 6-Chloro-1H-indole (cas: 17422-33-2Name: 6-Chloro-1H-indole).
6-Chloro-1H-indole (cas: 17422-33-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 6-Chloro-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles