Palladium-Catalyzed Benzannulations of 1-(Indol-2-yl)but-3-yn-1-ols: Easy Access to Functionalized Carbazoles was written by Pramanik, Subhendu;Chatterjee, Sarat;Banerjee, Rumjhum;Chowdhury, Chinmay. And the article was included in Organic Letters in 2022.Quality Control of 1-Methyl-1H-indole-2-carbaldehyde This article mentions the following:
An atom economic direct synthesis of carbazoles having aryl and keto-aryl groups has been achieved through Pd(II)-catalyzed cascade reactions between 1-(indol-2-yl)-3-butyn-1-ols and aldehydes. The reaction proceeds through alkyne-carbonyl metathesis, an uncommon pathway using palladium catalyst, and constitutes a fast intermol. assembly through four carbon-carbon bond formations in one-pot. Absence of the aldehyde substrate resulted in the formation of C1-aryl substituted carbazoles. The reaction is amenable to the synthesis of bis-carbazole derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8Quality Control of 1-Methyl-1H-indole-2-carbaldehyde).
1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 1-Methyl-1H-indole-2-carbaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles