Prasad, Bagineni; Das, Rabindra Nath; Jamroskovic, Jan; Kumar, Rajendra; Hedenstroem, Mattias; Sabouri, Nasim; Chorell, Erik published the artcile< The relation between position and chemical composition of bis-indole substituents determines their interactions with G-quadruplex DNA>, Application of C10H9NO2, the main research area is human DNA G quadruplex sidechain bis indole drug target; DNA structures; G-Quadruplexes; bis-indole; drug design; nitrogen heterocycles.
G-quadruplex (G4) DNA structures are linked to fundamental biol. processes and human diseases, which has triggered the development of compounds that affect these DNA structures. However, more knowledge is needed about how small mols. interact with G4 DNA structures. This study describes the development of a new class of bis-indoles (3,3-diindolyl-Me derivatives) and detailed studies of how they interact with G4 DNA using orthogonal assays, biophys. techniques, and computational studies. This revealed compounds that strongly bind and stabilize G4 DNA structures, and detailed binding interactions which for example, show that charge variance can play a key role in G4 DNA binding. Furthermore, the structure-activity relationships generated opened the possibilities to replace or introduce new substituents on the core structure, which is of key importance to optimize compound properties or introduce probes to further expand the possibilities of these compounds as tailored research tools to study G4 biol.
Chemistry – A European Journalpublished new progress about Animal gene, c-myc Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 93247-78-0 belongs to class indole-building-block, and the molecular formula is C10H9NO2, Application of C10H9NO2.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles