Electrophilicity and nucleophilicity of commonly used aldehydes was written by Pratihar, Sanjay. And the article was included in Organic & Biomolecular Chemistry in 2014.Quality Control of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
The present approach for determining the electrophilicity (E) and nucleophilicity (N) of aldehydes includes a kinetic study of KMNO4 oxidation and NaBH4 reduction of aldehydes. A transition state anal. of the KMNO4 promoted aldehyde oxidation reaction has been performed, which shows a very good correlation with exptl. results. The validity of the exptl. method has been tested using the exptl. activation parameters of the two reactions. The utility of the present approach is further demonstrated by the theor. vs. exptl. relationship, which provides easy access to E and N values for various aldehydes and offers an at-a-glance assessment of the chem. reactivity of aldehydes in various reactions. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Quality Control of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5-Chloroindole-3-carboxaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles