In an article, author is Turner, Danielle N., once mentioned the application of 283173-50-2, Formula: https://www.ambeed.com/products/283173-50-2.html, Name is Rucaparib, molecular formula is C19H18FN3O, molecular weight is 323.3641, MDL number is MFCD11977252, category is indole-building-block. Now introduce a scientific discovery about this category.
Aim: The current report describes the discovery of indole derivatives that synergize with standard antibiotics. Materials & methods: The antibacterial activities were determined using an optimized time-kill method, while viability of mammalian cells was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: The synergy is observed with methicillin- and vancomycin-resistant Staphylococcus aureus bacterial strains, against which the standard antibiotics show no activities of their own. Our indole derivatives in combination with antibiotics lack toxicity toward mammalian cells, do not promote the evolution of resistance of S. aureus in comparison to clinically established antibiotics, and likely work by permeabilizing bacterial cell membranes. Conclusion: The above-mentioned findings demonstrate the potential clinical applications of our indole derivatives. Graphical abstract
If you are interested in 283173-50-2, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/283173-50-2.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles