Reference of 3658-77-3, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 3658-77-3, Name is 4-Hydroxy-2,5-dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1O, belongs to indole-building-block compound. In a article, author is Budovska, Mariana, introduce new discover of the category.
The increasing diversity of small molecule libraries is a major source for the discovery of new drug candidates. In terms of this trend, we report the synthesis of five series 5-bromosubstituted derivatives of indole phytoalexins Types A-E using a straightforward synthetic approach. Novel compounds were screened in vitro for antiproliferative/cytotoxic activity against seven human cancer cell lines by MTT assay. Evaluation of their antiproliferative potency showed that the activity of some analogues was better or comparable to that of cisplatin and at the same time the toxicity of these compounds on 3T3 cells was lower than that of cisplatin. We found that all 5-bromosubstituted analogues of indole phytoalexins Types A-E exhibited lower or approximately the same activities as previously studied corrensponding non-brominated compounds.
Reference of 3658-77-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 3658-77-3.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles