Properties and Exciting Facts About 473257-60-2

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 473257-60-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 473257-60-2

Application of 473257-60-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.473257-60-2, Name is Ethyl 5-chloro-6-fluoro-1H-indole-2-carboxylate, molecular formula is C11H9ClFNO2. In a Article£¬once mentioned of 473257-60-2

2-Phenyl-3H-imidazo<4,5-b>pyridine-3-acetamides as Non-Benzodiazepine Anticonvulsants and Anxiolytics

A series of 2-phenyl-3H-imidazo<4,5-b>pyridine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytics based on a molecular disconnection of a typical 1,4-benzodiazepine (BZD).A number of these compounds showed submicromolar potency in a <3H>benzodiazepine binding assay in vitro and good potency in protecting rodents against pentylenetetrazole-induced seizures.Compound 84 appears to be a selective anticonvulsant (pentylenetetrazole) agent when tested against a profile of chemically and electrically induced seizures in mice.In adddition, compound148 appears to be a selective anxiolytic/hypnotic agent on the basis of biochemical and pharmacological characterization.It appears to be full BZD agonist as assessed by GABA shift ratio and to be effective in punishment and nonpunishment animal models of anxiety.In addition, it shows a lower side-effect profile than diazepam as assessed by rotorod neurotoxicity and potentiation of ethanol-induced sleep time in mice.The chemistry and structure-activity relationships of this series is discussed.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 473257-60-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 473257-60-2

Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles