Chemistry is an experimental science, 827-01-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 827-01-0, Name is 5-Chloroindole-3-carboxaldehyde
Chiral Imidodiphosphoric Acid-Catalyzed Highly Diastereo- and Enantioselective Synthesis of Poly-Substituted 3,4-Dihydro-2 H-pyrans: [4 + 2] Cycloadditions of beta,gamma-Unsaturated alpha-Ketoesters and 3-Vinylindoles
Imidodiphosphoric acids were employed to catalyze inverse-electron-demand hetero-Diels-Alder reaction of beta,gamma-unsaturated alpha-ketoesters and 3-vinylindoles. A series of optically active 3,4-dihydro-2H-pyran derivatives with three contiguous stereogenic centers was synthesized in excellent yields (70-99%), diastereoselectivities (>20:1), and enantioselectivities (73-99%). The resulting indole containing 3,4-dihydro-2H-pyran could be converted to tetrahydropyran derivatives, which appear in several biological active compounds by simple hydrogenation reduction.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 827-01-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 827-01-0, in my other articles.
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles