Synthetic Route of 526-55-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.526-55-6, Name is 3-Indoleethanol, molecular formula is C10H11NO. In a article，once mentioned of 526-55-6
To investigate whether melatonin has a direct action on the cardiovascular system, putative melatonin receptors were studied in quail heart membrane preparations using the specific melatonin agonist 2-[125I]iodomelatonin ([125I]Mel) as the radioligand. The [125I]Mel binding demonstrated in the mature quail heart was saturable, highly specific and reversible, of picomolar affinity and femtomolar density (Kd = 35.2 ± 5.2 pM; Bmax = 1.32 ±: 0.25 fmol/mg protein; n = 8). The linear Scatchard plots and the close to unity Hill coefficient indicated a single class of binding sites. The pharmacological profile was in the affinity order of 2-iodomelatonin = 2-phenylmelatonin > melatonin > 6-chloromelatonin >> 6-hydroxymelatonin > 6-sulphatoxymelatonin >> N-acetylserotonin >>> 5-hydroxytryptamine. Guanosine 5′-triphosphate and guanosine 5′-O-(3-thiotriphosphate) (GTPgammaS) dose dependently inhibited the binding. Ten muM GTPgammaS lowered the binding affinity by 50% in saturation studies. The order of potency of inhibition by cations was: Ca2+ > Mg2+ > Li+ > Na+ > K+ > choline chloride. Contrary to most other melatonin binding sites, millimolar concentrations of Ca2+ and Mg2+ did not promote binding in the quail heart membranes. In vitro autoradiography indicated homogeneous labeling in the heart. Our results demonstrated [125I]Mel binding sites in the quail heart. That guanine nucleotides and Na+ inhibited the binding indicated that these putative melatonin receptors are coupled to guanine nucleotide-binding proteins (G-proteins).
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles