In an article, author is Prasad, Avvari N., once mentioned the application of 91-68-9, Recommanded Product: 3-Diethylaminophenol, Name is 3-Diethylaminophenol, molecular formula is C10H15NO, molecular weight is 165.2322, MDL number is MFCD00002265, category is indole-building-block. Now introduce a scientific discovery about this category.
Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions
An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene substrates such as malononitrile and ethyl 2-cyano acetate. This reaction proceeds smoothly and obtained good to excellent yields (68-93%) using water as green solvent under ambient conditions. The obtained products were confirmed by H-1, C-13 NMR, and mass spectroscopy techniques. The one-pot MCR occurs through formation of Knoevenagel adducts then followed by Michael addition of indole.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles