Synthetic Route of 480-41-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 480-41-1, Name is (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, SMILES is O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3, belongs to indole-building-block compound. In a article, author is Fu, Dong-Jun, introduce new discover of the category.
Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells
A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogues, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyeacetamide (V7) showed the best inhibitory activity against MGC803 cells with an IC50 value of 1.59 mu M. Cellular mechanisms elucidated that V7 inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analogue V7 inhibited NEDDy-lation pathway and MAPK pathway against MGC803 cells.
Synthetic Route of 480-41-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 480-41-1 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles